Chlormadinone acetate (CMA) yog ib qho muaj zog progesterone receptor (PR) agonist, ib feem androgen receptor (AR) antagonist thiab tsis muaj zog glucocorticoid receptor (GR) antagonist.Chlormadinone khi rau PRs, uas induces qhov kev qhia ntawm progesterone-responsive noob.
Khoom npe | Chlormadinone acetate |
Tshuaj npe | 17a-acetoxy-6-chloro-4,6-pregnadiene-3,20-dione |
Lwm Lub Npe | Clormadinoneacetate; chloromadinone17-acetate; 6-Chloro-17-acetoxy-4,6-pregnadiene-3,20-dione; 17a-Acetoxy-6-chloro-4,6-pregnadiene-3,20-dione, 6-Chloro- 6-dehydro-17a-acetoxyprogesterone, Gestafortin, Matrol, Menstridyl, 6-Chloro-17a-hydroxy-4,6-pregnadiene-3,20-dione17-acetate; 17-alpha-acetoxy-; Tshuaj phau ntawvlormadinoneacetate-17- -Chloro-4,6-pregnadiene-3,20-dione,6-Chloro-17α-hydroxy-4,6-pregnadiene-3,20-dione17-acetate,6-Chloro-6-dehydro-17a-acetoxyprogesterone,Gestafortin , Matrol, Mens; (8R, 9S, 10R, 13S, 14S, 17R)-17-acetyl-6-chloro-10,13-diMethyl-3-oxo-2,3,8,9,10,11,12 ,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-ylacetate |
CAS Nr | 302-22-7 : kuv |
Molecular Formula | C23H29ClO4 |
Formula hnyav | 404.93 ib |
Qhov tshwm sim | Dawb rau daj crystalline hmoov;Tsis muaj ntxhiab, Tasteless |
Assay | 98.0% min |
Melting Point | 212 ° C |
Boiling Point | 512.5 ± 50.0 ° C |
Absorption Peak | 1.1345 g / cm3 |
Pob | 20kg / hnab / nruas, 25kg / hnab / nruas, lossis raws li koj xav tau |
Cia | Khaws lub thawv kaw kom nruj rau hauv qhov chaw qhuav thiab txias.Tsis txhob raug tshav ntuj ncaj qha. |
COA & MSDS | Muaj |
Daim ntawv thov | Rau kev tshawb fawb |
TEST | ACCEPTANCE CRITERIONS | TSEEM CEEB |
Kev txheeb xyuas | TLC | Qhov zoo |
UV spectrum | Qhov zoo | |
IR spectrum | Qhov zoo | |
Yam ntxwv | Dawb los yog yellowish crystalline hmoov | ua raws |
Melting point | 211 ~ 215 ℃ | 211 ~ 214 ℃ |
Kev sib hloov kho qhov muag tshwj xeeb | ﹣10° ~ ﹣14° | ﹣ 12.5° |
Solubility | Dawb soluble nyob rau hauv chloroform, soluble nyob rau hauv acetonitrile, me ntsis soluble nyob rau hauv ethanol thiab ether thiab pratcically insoluble nyob rau hauv dej. | ua raws |
Poob rau ziab | ≤ 0.5% | 0.21% |
Residue ntawm ignition | ≤0.1% | 0.04% |
Lwm cov tshuaj steroids | ≤ 1.0% | 0.59% |
Cov hlau hnyav | ≤ 20ppm | Hla |
Arsenic | ≤ 2 ppm | Hla |
Assay | ≥98.0% | 98.9% |
Residual solverts (GC) | Acetone ≤5000ppm Methanol ≤3000ppm Pyridine ≤ 200ppm | Hla Hla Hla |
Chlormadinone acetate yog ib qho tshuaj progestin thiab antiandrogen uas yog siv rau hauv cov tshuaj tiv thaiv kev xeeb tub los tiv thaiv kev xeeb tub, raws li ib feem ntawm menopausal hormone therapy, hauv kev kho mob gynecological, thiab hauv kev kho mob ntawm androgen-dependent tej yam kev mob xws li mob prostate thiab prostate cancer hauv txiv neej thiab pob txuv thiab hirsutism hauv cov poj niam.
Kuv yuav tsum noj Chlormadinone acetate li cas?
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Lub sijhawm ua haujlwm
≤100kg: hauv peb hnub ua haujlwm tom qab tau txais cov nyiaj them poob haujlwm.
>100kg: ib lis
Qauv
Muaj.
Pob
20kg / hnab / nruas, 25kg / hnab / nruas
los yog raws li koj xav tau.
Cia
Khaws lub thawv kaw kom nruj rau hauv qhov chaw qhuav thiab txias.
Tsis txhob raug tshav ntuj ncaj qha.