Qhov kev sim qhia tau hais tias muaj ntau zaus ntawm cov tshuaj tua kab mob quaternary ammonium raws li kev kho mob rau ntau tus kab mob, suav nrog tus mob coronaviruses: cov no ua los ntawm kev ua kom lub cev tiv thaiv lipid txheej uas ntim cov kab mob xws li SARS-CoV-2 cia siab rau.Quaternary ammonium compounds tau pom zoo los tua cov kab mob thiab muaj ntau dua 350 cov khoom lag luam ntawm EPA's List N: Cov tshuaj tua kab mob rau kev siv tawm tsam SARS-CoV-2 (Cov Khoom Siv Ntxiv. Cov tshuaj tua kab mob ntau dua thiab lub sijhawm sib cuag (koom nrog ntau yam kab mob) rau ntau yam tshuaj tua kab mob. Cov tshuaj nyob rau hauv EPA daim ntawv teev npe tau tshaj tawm thiab> 140 tuaj yeem cuam tshuam tus kab mob hauv ob peb feeb (18).
Cov ntaub ntawv no tau coj peb mus rau kev tshawb nrhiav loj dua rau quaternary ammonium compounds nrog kev ua haujlwm tiv thaiv tus kabmob coronaviruses thiab muaj peev xwm txheeb xyuas cov tshuaj uas twb tau sim hauv tsev kho mob thiab tuaj yeem siv los ua qhov kev kho mob rau COVID-19.Ib qho ntawm cov tshuaj tua kab mob uas tau pom tias muaj kev puas tsuaj rau cov kab mob (Cov Khoom Siv Ntxiv) thiab siv dav hauv cov khoom tu tus kheej yog cetylpyridinium chloride.Cov tshuaj no pom muaj feem ntau hauv cov tshuaj ntxuav qhov ncauj thiab tau teev tseg los ntawm FDA raws li Kev Saib Xyuas Kev Nyab Xeeb (GRAS) xws li tias nws tseem raug siv los ua cov tshuaj tua kab mob rau cov nqaij thiab nqaij qaib (txog 1%).Cetylpyridinium chloride tau siv rau hauv ntau qhov kev sim tshuaj, suav nrog kev kho mob tiv thaiv kab mob ua pa kom siv tau raws li kev siv tshuaj tua kab mob.Cetylpyridinium yuav txhawb nqa tus kab mob inactivation los ntawm kev rhuav tshem lub capsid nrog rau los ntawm nws cov lysosomotropic kev txiav txim, uas, raws li tau hais los saum toj no, yog ib yam rau quaternary ammonium tebchaw.Qhov no ua rau muaj lus nug txog seb qee cov tshuaj tau txheeb xyuas nrog cov tshuaj tiv thaiv kab mob tiv thaiv SARS-CoV-2 hauv vitro coj zoo ib yam, xws li lawv tuaj yeem rhuav tshem tus kab mob capsid nrog rau kev sib sau hauv lysosome lossis endosomes thiab thaum kawg thaiv cov kab mob nkag.Cov kev tshawb fawb luam tawm ntxiv tau qhia tias cov nyhuv no tuaj yeem txo qis los ntawm kev siv Cathepsin-L inhibitors.
Cetylpyridinium chloride (CPC)
Quaternary ammonium tebchaw nrog kev paub txog tus kabmob coronavirus
| Molecule | Antiviral kev ua haujlwm | Mechanism | FDA pom zoo | Siv |
| Ammonium Chloride | Murine coronavirus, kab mob siab C, | Lysosomotropic | Yog lawm | Kev siv ntau yam suav nrog metabolic acidosis. |
| Cetylpyridinium chloride | Influenza, kab mob siab B, poliovirus 1 | Targets capsid thiab yog lysosomotropic | Yog, GRAS | Antiseptic, tshuaj ntxuav qhov ncauj, hnoos lozenges, khoom tu tus kheej, tshuaj ntxuav tes thiab lwm yam. |
Post lub sij hawm: Aug-03-2021