Olivetol, tseem hu ua 5-pentylresorcinol, yog ib qho kev sib xyaw ua ke uas tau txais kev saib xyuas ntau hauv xyoo tas los no rau nws cov kev siv tshuaj thiab kev lag luam.Nws yog lub hauv paus molecule rau biosynthesis ntawm ntau lub tebchaw, suav nrog cannabinoids pom feem ntau hauv cov nroj tsuag cannabis.Nkag siab txog biosynthesis ntawmolivetolNws yog ib qho tseem ceeb kom paub txog nws lub peev xwm thiab tshawb nrhiav nws ntau yam kev siv.
Biosynthesis ntawmOlivetolpib nrog lub condensation ntawm ob lub molecules ntawm malonyl-CoA, muab los ntawm acetyl-CoA, los ntawm kev ua ntawm ib qho enzyme hu ua polyketide synthase.Cov tshuaj tiv thaiv condensation no ua rau tsim cov khoom nruab nrab hu ua geranyl pyrophosphate, uas yog ib qho ua ntej hauv biosynthesis ntawm ntau yam khoom ntuj tsim, suav nrog terpenes.
Geranyl pyrophosphate yog tom qab ntawd hloov mus rau hauv txiv roj roj los ntawm cov tshuaj tiv thaiv enzymatic.Thawj kauj ruam yuav hloov ib pawg isoprenyl los ntawm geranyl pyrophosphate mus rau hexanoyl-CoA molecule, tsim ib qho chaw hu ua hexanoyl-CoA olive acid cyclase.Cov tshuaj tiv thaiv cyclization no yog catalyzed los ntawm ib qho enzyme hu ua hexanoyl-CoA: olivelate cyclase.
Cov kauj ruam tom ntej hauvolivetolbiosynthesis suav nrog kev hloov pauv ntawm hexanoyl-CoA olivetate cyclase rau hauv daim ntawv nquag hu ua tetraketide intermediate.Qhov no tau ua tiav los ntawm cov tshuaj tiv thaiv enzymatic catalyzed los ntawm enzymes xws li chalcone synthase, stilbene synthase, thiab resveratrol synthase.Cov tshuaj tiv thaiv no ua rau tsim cov tetraketide intermediates, uas tom qab ntawd hloov mus rau olivetol los ntawm kev ua ntawm polyketide reductase.
Ib zaugolivetolyog synthesized, nws tuaj yeem hloov pauv mus rau ntau lub tebchaw, suav nrog cannabinoids, los ntawm kev ua ntawm enzymes xws li cannabidiolic acid synthase thiab delta-9-tetrahydrocannabinolic acid synthase.Cov enzymes no catalyze lub condensation ntawmolivetolnrog geranyl pyrophosphate los yog lwm yam precursor molecules los tsim cov cannabinoids sib txawv.
Ntxiv rau nws lub luag haujlwm hauv cannabinoid biosynthesis,olivetoltau pom tias muaj peev xwm tiv thaiv kab mob thiab antioxidant zog.Cov kev tshawb fawb tau qhia tiasolivetoltuaj yeem cuam tshuam kev loj hlob ntawm ntau yam kab mob fungal, ua rau nws muaj kev vam meej tus neeg sib tw rau kev txhim kho cov tshuaj tiv thaiv kab mob.Ntxiv thiab,olivetoltau pom tias muaj cov kev ua kom muaj zog pov tseg tawm tsam dawb radicals, uas yog cov reactive molecules uas tuaj yeem ua rau puas hlwb thiab cov ntaub so ntswg.Qhov no antioxidant khoom ntawmolivetolqhia tias nws muaj peev xwm siv los tsim cov tshuaj kho mob rau kev kho cov kab mob oxidative kev nyuaj siab.
Hauv kev xaus, biosynthesis ntawmolivetolKev koom tes nrog cov condensation ntawm malonyl-CoA molecules, tom qab ntawd los ntawm cov tshuaj tiv thaiv enzymatic, ua rau muaj kev tsim ntawmolivetol.Qhov sib xyaw ua ke no ua haujlwm ua ntej molecule hauv biosynthesis ntawm cannabinoids thiab lwm yam khoom ntuj.Nkag siab txog txoj kev biosynthetic ntawmOlivetolNws yog ib qho tseem ceeb rau kev txhim kho nws cov peev txheej hauv kev lag luam tshuaj thiab kev lag luam.Kev tshawb fawb ntxiv rau hauv biosynthesis ntawmolivetolthiab nws cov derivatives tuaj yeem ua rau kev tshawb pom ntawm cov tshuaj kho tshiab thiab pab txhim kho cov tshuaj tshiab.
Post lub sij hawm: Nov-13-2023